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سی و دومین کنفرانس ملی و دهمین کنفرانس بین المللی مهندسی زیست پزشکی ایران
Analyzing Blood Glucose Levels with Near Infra-Red Spectroscopy and Chemometric Multivariate Methods
Authors :
Hadi Barati
1
Arian Mousavi Madani
2
Soheil Moradi
3
Mohammad Mohsen Ebrahimi Seyghalan
4
Mehdi Fardmanesh
5
1- Sharif University of Technology
2- Sharif University of Technology
3- Sharif University of Technology
4- Sharif University of Technology
5- Sharif University of Technology
Keywords :
Blood glucose،near infrared،Lambert-Beer law،principal components regression،molar absorptivity
Abstract :
In this work, the blood NIR absorbances are recorded using the FT-IR method. It is shown that when the absorbance curves are multiplied by the first derivative of the water absorbance spectrum as well as by the first derivative of the glucose absorbance, the peaks related to the water interferent in the blood are effectively removed from the blood absorbance spectra, allowing for better distinction of the peaks of the blood glucose. The PCR prediction using this method shows smaller errors compared to the PCR employing the net absorbances, while the number of derived principal components is smaller in the PCR method based on the derivatives than the one based on the net absorbances. Additionally, the prediction of blood glucose levels using a linear regression model based on the molar absorptivity of glucose also demonstrates acceptable accuracy.
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