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3D Printing of Novel Bioactive Polycaprolactone Nanocomposites for Prospective Osteoporotic Bone Defect Engineering

Authors :

Fateme Fathi¹ Hengameh Zolala² Farhad Esmailzadeh³ Shohreh Mashyekhan⁴ Irinia Kurzina⁵

1- دانشگاه صنعتی شریف 2- دانشگاه صنعتی شریف 3- دانشگاه صنعتی شریف 4- دانشگاه صنعتی شریف 5- Tomsk State University

Keywords :

Osteoporosis،3D printed PCL-based scaffold،mesoporous bioactive glass nanoparticles،bioactive scaffold،Nanocomposites

Abstract :

— Osteoporotic bone defects pose a major clinical challenge, demanding scaffolds that combine mechanical support with bioactivity to stimulate bone regeneration. In this study, we developed a novel 3D-printed polymeric scaffold coated with APTES-functionalized mesoporous bioactive glass nanoparticles (MBGNPs) nanoparticles to address this need. The scaffold featured a four-layer architecture with 800 µm cubic pores, optimized for potential osteoblast adhesion and proliferation. MBGNPS nanoparticles and surface functionalized MBGNPSs were synthesized and thoroughly characterized by using FE-SEM, EDS, XRD, and FTIR analyses; to confirm their mesoporous structure and chemical composition. Additionally, Scaffold characterization confirmed successful nanoparticle deposition, preservation of pore architecture, and chemical integration of the coating. This study demonstrates a simple and effective strategy to fabricate mechanically robust, bioactive polymeric scaffolds, highlighting their potential as platforms for future osteoporotic bone defect engineering applications.