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A Comparative Analysis of Simulated and Experimental Acoustic and Thermal Behavior of HIFU

Authors :

Maryam Fazeli¹ Remi Souchon² Cyril Lafon³ Mehran Jahed⁴

1- Department of Electrical Engineering, Sharif University of Technology, / LabTAU 2- LabTAU 3- LabTAU 4- Faculty Member, Sharif University of Technology

Keywords :

Acoustic Pressure Field،Bioheat Transfer،numerical Modelling،Experimental Validation،High-Intensity Focused Ultrasound (HIFU)،Thermal Ablation

Abstract :

High-Intensity Focused Ultrasound (HIFU) is a promising technique for non-invasive thermal ablation in biomedical applications. Computational models are frequently used to guide the clinical optimization of HIFU; however, thorough experimental validation is necessary to ensure their predictive accuracy. This study provides a validation of a k-Wave-based computational model by contrasting its predictions with experimental data from an ex-vivo porcine liver. Initially, using an appropriate hydrophone, the acoustic pressure field of a HIFU transducer was measured. Next, using the k-Wave toolbox, numerical simulation of the acoustic field in heterogeneous media was conducted. Subsequently, the thermal ablation effects were evaluated by comparing the dimensions of the physical lesion in the porcine liver to the lesion predicted by a thermal dose model. With a mean percentage difference of 2.7% for the axial length and 33.3% for the transverse width for the lesion dimensions, the results demonstrated good agreement between the experimental and simulation results. These findings confirm the fidelity of the computational model, supporting its use for future HIFU treatment planning and optimization.