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Optimization of an Integrated Filter Photometric system and a Centrifugal Microfluidic System for Biochemical Analysis

Authors :

Bahareh Mohammadi Jobani¹ Amin Dehghan² Zahra Shahsavari³ Esmail Pishbin⁴

1- دانشگاه علوم پزشکی شهید بهشتی 2- دانشگاه علم و صنعت ایران 3- دانشگاه علوم پزشکی شهید بهشتی 4- سازمان پژوهش علمی و صنعتی ایران

Keywords :

Filter photometers،POCT،Centrifugal microfluidics،Siphon valves،Biochemical markers

Abstract :

Microfluidic systems are rapidly advancing, particularly when integrated with medical science to enhance laboratory services. Key benefits of microfluidics, such as portability, the ability to multiplex several tests, and low reagent requirements, create a broad research area, especially in laboratory detection systems. Photometer-based analyzers are the most common detectors for medical tests, including absorbance and fluorescence-based detectors that cover a wide range of detection analyses. This study aimed to develop an optimized centrifugal microfluidic system integrated with a custom vertical filter-photometer. The compact design, which incorporates miniaturized filters and lenses, was engineered to achieve a precision and accuracy comparable to commercial autoanalyzers. For this purpose, a centrifugal microfluidic device was designed and optimized with a focus on siphon channel actuation for biochemical analysis. Human serum samples, with previously analyzed biomarker data, were obtained from the Parseh lab. To validate the microfluidic and the optical setup's functionality, three common metabolic tests were selected: glucose, triglycerides, and cholesterol. Human serum was injected into the disc, and the subsequent analysis, along with the calibrator test, was performed on the same disc. The results of light absorbance for these tests on disc microfluidic using the optical setup showed a high correlation (R² above 0.99 for all three tests) with the reported results from the Parseh lab, which served as the reference. Finally, to minimize the bias observed between our results and the reference results, an algorithm was developed to predict optimized data for new tests. Based on the findings, this filter photometer setup has the potential to be enhanced with additional filters for comprehensive biochemical tests analyzed through optical absorbance systems, and along with optimized microfluidic devices, can be introduced for POCT systems.

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