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Carbon Nanotube Mediated Hyperthermia for Cancer Therapy

Authors :

Behnam Zeinali¹ Afsaneh Mojra²

1- دانشگاه صنعتی خواجه نصیرالدین طوسی 2- دانشگاه صنعتی خواجه نصیرالدین طوسی

Keywords :

Carbon nanotubes،hyperthermia،nanoparticle heating،computational modeling،cancer

Abstract :

Carbon nanotube (CNT) mediated hyperthermia has emerged as a promising approach for cancer therapy, offering localized heating with high thermal efficiency. This study presents a computational framework that systematically evaluates the effects of CNT concentration and applied power on tumor temperature distribution and necrosis development. An axisymmetric tumor model incorporating interstitial fluid flow, nanoparticle transport, bioheat transfer, and Arrhenius-based damage assessment was employed. The results demonstrate that increasing CNT concentration and power density significantly elevates maximum tumor temperature (up to 52% increase) and accelerates necrosis onset, reducing the time to irreversible tissue damage from over 1000 s to less than 200 s. However, excessive escalation was shown to extend irreversible necrosis into adjacent healthy tissue, highlighting the delicate balance between treatment efficacy and safety. These findings provide clinically relevant insights that support the optimization of CNT dose and power modulation to achieve effective and safe tumor ablation.