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Engineering pH-Responsive Hybrid Hydrogels via Inverse Suspension Polymerization for Novel Drug Delivery Systems

Authors :

Borhan Oghbaei Bonab¹ Mohammad Ashraf² Sahar Enayati³ Alireza Mahjub⁴

1- دانشگاه صنعتی امیرکبیر 2- دانشگاه صنعتی امیرکبیر 3- دانشگاه صنعتی امیرکبیر 4- دانشگاه صنعتی امیرکبیر

Keywords :

Chitosan،Drug Delivery،Hydrogel،Inverse suspension polymerization

Abstract :

Hydrogels have attracted considerable attention as advanced platforms for intelligent drug delivery systems owing to their three-dimensional structure, favorable biocompatibility, and ability to encapsulate and release therapeutic agents in a controlled and targeted manner. However, the inherent limitations of natural hydrogels, such as poor mechanical strength, along with the shortcomings of synthetic hydrogels, including lack of biodegradability, restrict their optimal biomedical applications. The development of hybrid hydrogels, which combine natural and synthetic polymers, provides an effective strategy to overcome these drawbacks and to achieve materials with enhanced mechanical integrity, suitable biocompatibility, and efficient responsiveness to physiological stimuli. In this study, a pH-responsive hybrid hydrogel based on chitosan and acrylate monomers was synthesized and characterized via inverse suspension polymerization. The results demonstrated that the obtained spherical microparticles exhibited desirable structural and functional properties, highlighting their significant potential for application in next-generation, targeted drug delivery systems.