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Electrospun Chitosan-Gelatin/ZIF‑8 Nanofibers Scaffolds for Enhanced Wound Healing

Authors :

Maryam Nosrati hashi¹ Maryam Tajabadi² Fateme Mirzajani³ Alireza Khavandi⁴

1- دانشگاه علم و صنعت ایران 2- دانشگاه علم و صنعت ایران 3- دانشگاه شهید بهشتی 4- دانشگاه علم و صنعت ایران

Keywords :

wound dressing،electrospinnig،nanofibers،ZIF-8،chitosan،gelatin

Abstract :

Wound healing poses a major public health challenge, exacerbated by the growing burden of chronic diseases and aging populations. Electrospun nanofibrous dressings offer unique advantages high surface-to-volume ratio, tunable porosity, and the capacity to deliver bioactive agents to accelerate tissue repair. Herein, we report the fabrication and evaluation of chitosan-based nanofibers embedded with zinc imidazolate framework 8 (ZIF-8) nanoparticles for enhanced antibacterial activity. ZIF-8 particles were synthesized via coordination of zinc nitrate with 2 methylimidazole, yielding uniform nanoparticles (138 ± 34 nm). Subsequent electrospinning under optimized conditions produced smooth, bead free nanofibers averaging 213 ± 31 nm in diameter. Structural and compositional analyses SEM, FTIR, EDS, and elemental mapping confirmed nanoparticle incorporation without compromising fiber morphology. Antibacterial assays revealed 90% inhibition of Escherichia coli and 10% inhibition of Staphylococcus aureus. Collectively, these results highlight the potential of chitosan/ZIF 8 electrospun mats as advanced wound dressings capable of preventing infection and promoting healing.