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Fixed-Frequency Impedimetric Detection of Sickle Cells Using Interdigitated Electrodes

Authors :

َArezoo Savlani¹ Mobina Ghanbari² Mohammadjavad Bouloorchi Tabalvandi³ Majid Badieirostami⁴

1- دانشگاه تهران 2- دانشگاه تهران 3- دانشگاه تهران 4- دانشگاه تهران

Keywords :

Sickle cell disease (SCD)،impedimetric detection،red blood cells (RBCs)،interdigitated electrodes،fixed-frequency measurement

Abstract :

Sickle cell disease (SCD) causes red blood cells (RBCs) to adopt an abnormal, stiff, crescent-like shape, impairing their ability to flow smoothly through small blood vessels and disrupting normal circulation. These morphological changes are associated with altered blood function and clinical complications, making rapid and accurate detection of sickle cells essential for disease monitoring and management. In this study, we presented an impedimetric detection approach using interdigitated comb electrodes combined with fixed-frequency electrical impedance measurement. As RBCs pass through the sensing region, impedance variations were recorded and analyzed, allowing reliable differentiation between normal and sickle cells. Numerical results demonstrated that sickled RBCs exhibit distinct impedance profiles compared with healthy cells. This label-free, real-time method is well suited for miniaturized platforms and can be seamlessly integrated into lab-on-a-chip devices. The proposed system provides a versatile framework for developing rapid, point-of-care diagnostic tools and offers potential applications in monitoring SCD and other blood disorders. By combining insights from cellular biophysics with microelectrode engineering, this technique highlights the promise of fixed-frequency impedimetric measurements as a scalable and accurate strategy for cellular characterization in biomedical engineering research and applications.